Traditionally the patient enrollment in clinical trials is always through the clinical sites or investigational sites (medical center, hospital, clinic,...). With the new technologies and the trend of patient centered approach in clinical trials, the concept of virtual clinical trial has been formed. In 2011, Pfizer announced their first virtual clinical trial. Today's NPR reported another virtual clinical trial in ALS "Simplified Study Aims To Quickly Test A Long-Shot ALS Treatment". If the virtual trial can be accepted by the medical community and the regulatory authorities, it will significantly lower the cost for conducting clinical trials.