Saturday, August 15, 2015

Tipping point analysis - multiple imputation for stress test under missing not at random (MNAR)

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In a previous post , different imputation methods were summarized by the different missingness assumptions. One method, the tipping point a...
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Friday, August 07, 2015

A SKEPTIC'S GUIDE TO HEALTH NEWS AND DIET FADS; A BOGUS STUDY TREATED AS REAL

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In this weekend's NPR on the media, "a skeptic's guide to health news and diet fads" was discussed. It mentioned a story ...
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Tuesday, July 28, 2015

Clinical Research Toolkit by NIH and NCI

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NIH (National Institute of Health) has been the force in conducting the landmark clinical trials and conducting the clinical trials in the...
Saturday, July 18, 2015

Dose Linearity versus Dose Proportionality

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In early phase studies of the drug development, dose linearity and dose proportionality are usually tested. It is essential to determine wh...
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Friday, July 03, 2015

Protocol Deviation versus Protocol Violation and its Classifications (minor, major, critical, important)

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Every clinical trial will have a study protocol. The investigator is required to follow the study protocol to conduct the study. However, du...
Sunday, June 14, 2015

Sample Size and Power Calculation Using SAS Proc Power and twosamplesurvival Statement

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For sample size and power calculations, several commercially available software can be used. The commonly used ones are EAST , PASS , and NQ...
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