Saturday, June 21, 2014

Is MMRM Good Enough in Handling the Missing Data in Longitudinal Clinical Trials?

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In last 7-8 years, there is a gradual shift from using the single-imputation method such as LOCF to MMRM (mixed model for repeated measurem...
Tuesday, June 10, 2014

Mixed effect Model Repeat Measurement (MMRM) and Random Coefficient Model Using SAS

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The clinical trial data presented to us are often in longitudinal format with repeated measurements. For Continuous Endpoints in Longitudin...
3 comments:
Sunday, June 08, 2014

Meetings Materials on FDA's website

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Because of the FDA Transparency Initiative , the meetings, conferences, and workshops sponsored or co-sponsored by FDA are not open to the p...
Saturday, May 03, 2014

Some quotes about statistics or from statisticians

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I often see people cite interesting quotes in their presentation. Citing a good quote can entice the audience. I recently saw a presentatio...
3 comments:
Thursday, May 01, 2014

New books about 'missing data in clinical trials'

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Missing data is one of the critical issues in statistics and in clinical trials. Three new books about the missing data were written by the ...
Sunday, April 06, 2014

Simulation Approach to estimate the sample size for Poisson distribution

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FDA Guidance for Industry: Safety, Efficacy, and Pharmacokinetic Studies to Support Marketing of Immune Globulin Intravenous (Human) as Rep...
Sunday, March 30, 2014

Computing Confidence Interval for Poisson Mean

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For Poisson distribution, there are many different ways for calculating the confidence interval. The paper by Patil and Kulkarni discusses...
5 comments: