On Biostatistics and Clinical Trials

As stated in Demets ' paper "Liability issues for data monitoring committee members" (Clinical Trials 2004; 1: 525–531): In ra...

When we perform the correlation analysis, we typically calculate the correlation coefficient and then test if this correlation coefficient i...

The Wall Street Journal (2/19, Wang) reports, "Most testing for the US drug industry's late-stage human trials is now done at site...

New York Times had a series of articles to explore medical treatments used despite scant proof they work and examining steps toward medicine...

Cronbach's Alpha is a tool for assessing the reliability of scales (for example a quality of life instrument). Cronbach's alpha can ...

Blood plasma, or plasma, is prepared by obtaining a sample of blood and removing the blood cells. The red blood cells and white blood cells ...

DMC (Data Monitoring Committee) vs. DSMB (Data Safety Monitoring Board) are the same thing. The term DMC is used more now because it is the ...

Everybody with basic statistical knowledge should understand the differences between the standard deviation (SD) and the standard error of m...

In statistics or biostatistics, the multiple comparisons problem occurs when one considers a set, or family, of statistical inferences simul...

members of the FDA's oncology Drugs Advisory Committee cautioned sponsors against treating retrospective clinical trial biomarker analys...

Data dredging (data fishing, data snooping) is the inappropriate (sometimes deliberately so) search for 'statistically significant'...

EQ-5D is a standardized instrument for use as a measure of health outcome. Applicable to a wide range of health conditions and treatments, i...

The followings are copied from PARADE (Jan 11, 2009). I am not sure if these arguments (or suggestions) have any scientific merit, but I cop...

The recently-enacted FDA Amendments Act (“FDAAA”) has lots of requirements that may have impact on statistical analysis and programming. It...

People can be confused about the interpretation of the correlation coefficient, especially when we observe a small, but statistically signif...

Vision is typically reported as xxx/yyy where the xxx value is usually 20 for US assessments. As vision gets worse, for the same numerator, ...

From " http://www.delawareonline.com/article/20081230/BUSINESS/812300331 " AstraZeneca is considering joining several of its peers...

Biosimilars or Follow-on biologics are terms used to describe officially approved new versions of innovator biopharmaceutical products, fo...

I have been thought that the chinese traditional medicine from herbal is typically safe. However, recent discussions with my friends make me...

Sub-grouping damages the balance obtained by randomization If the randomization is stratified for one factor (for example, disease severity)...