Showing posts with label randomization. Show all posts
Showing posts with label randomization. Show all posts
Friday, February 14, 2025

Understanding Mis-Stratification in Randomized Controlled Clinical Trials

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Stratified randomization is a common practice in randomized, controlled clinical trials. It ensures that key characteristics are evenly dis...
Saturday, December 28, 2024

Known knowns and Unknown Unknowns

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On several occasions during scientific presentations, I have come across citations of Donald Rumsfeld's statement. Donald Rumsfeld was o...
Monday, May 30, 2022

Clinical trials with external control, historical control, concurrent control, contemporaneous control, and synthetic control

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Three critical features for modern clinical trials are control, randomization, blinding. For the golden standard of RCTs (randomized control...
Monday, April 11, 2022

Randomization and elements of randomization specifications

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Randomization is the process of assigning trial subjects to treatment or control groups using an element of chance to determine the assignme...
Monday, April 04, 2022

Common Issues in Implementing Randomization and Blinding

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Randomization and blinding are two techniques to help prevent (conscious or unconscious) bias in clinical trials and they are the cornerston...
Tuesday, February 01, 2022

Randomization, Re-Randomization, and Micro-Randomization

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 I recently saw a Twitter post mentioning " Micro-Randomized Study Design Example - Maryland Alcohol-Dependent Moms Abstinence (MAMA) S...
Monday, February 22, 2021

Randomization Using Envelopes In Randomized, Controlled, and Blinded Clinical Trials

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I read an article by Clark et al “ Envelope use and reporting in randomized controlled trials: A guide for researchers ”. The article remind...