Showing posts with label Statistics. Show all posts
Showing posts with label Statistics. Show all posts
Thursday, August 18, 2022

Handling of values below or above a threshold (Below the Low Limit of Quantification or Above the Upper Limit of Quantification)?

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In clinical trials, the samples are often collected and sent to the central laboratory or specialty laboratory for measuring certain paramet...
Monday, January 17, 2022

Paired T-test and McNemar's test for paired data based on the summary data

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Sometimes, it is necessary for us to calculate the p-values based on the summary (aggregate) data without the individual subject level data....
1 comment:
Sunday, August 29, 2021

Retire Statistical Significance and p-value? - Revisited

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In 2019, there was a public debate about the use or misuse of statistical significance and p-values. I wrote a post about it " Retire ...
Monday, August 09, 2021

Randomized Withdrawal Design in Practice - Story of the HARMONY Trial

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In previous posts, we discussed the " Randomized Withdrawal Design and Randomized Discontinuation Trial " and " Randomized Wi...
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Sunday, June 20, 2021

Early Phase Trial to Find Maximal Tolerated Dose (MTD) - 3+3, CRM, and BOIN Designs

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In early-phase clinical trials, determining the dose range and therapeutic window is critical. The purpose of the early-phase studies may ju...
1 comment:
Monday, April 19, 2021

Restricted Mean Survival Time (RMST) for Handling the Non-Proportional Hazards Time to Event Data

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Time to event analysis (or traditionally survival analysis) is one of the most common analyses in clinical trials. In general, the time to e...
Monday, April 05, 2021

Non-proportional Hazards: how to analyze the time-to-event data?

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Time to event data is one of the most common data types in clinical trials. Traditionally, the log-rank test is used to compares the surviva...
3 comments:
Monday, February 01, 2021

BLQs (below limit of quantification) and LLOQ (Lower Limit of Quantification): how to handle them in analyses?

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In data analyses of the clinical trial, one type of data is the laboratory data containing the results measured by the central laboratory or...
2 comments: